BODIPY-Based Molecular Probe for Imaging of Cerebral beta-Amyloid Plaques

作者：Ono Masahiro^*; Watanabe Hiroyuki; Kimura Hiroyuki; Saji Hideo

来源：ACS Chemical Neuroscience, 2012, 3(4): 319-324.

DOI：10.1021/cn3000058

• Alzheimer's disease
• beta-amyloid plaque
• BODIPY
• optical imaging

We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of beta-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic A beta aggregates. beta-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In addition, the labeling of beta-amyloid plaques was demonstrated in vivo in Tg2576 mice. These results suggest BAP-1 to be a useful fluorescent probe for the optical imaging of cerebral beta-amyloid plaques in patients with Alzheimer's disease.

• 出版日期2012-4