Multiple autoimmune syndrome revealed by nephrogenic diabetes insipidus and hypokalaemic paralysis

作者：Zhang J; Lin H^*; Yu C; Peng H; Bai R

来源：Lupus, 2013, 22(11): 1178-1181.

DOI：10.1177/0961203313499416

• Autoimmune thyroid disease
• Hashimoto's thyroiditis
• Sjogren's syndrome
• systemic lupus erythematosus

A presentation of postpartum polydipsia and polyuria followed by periodic weakness led to the diagnosis of nephrogenic diabetes insipidus and hypokalaemic paralysis, both of which are complications of primary Sjogren's syndrome (pSS). The clinically dominant pSS was taken to coexist with long-latent systemic lupus erythematosus and asymptomatic autoimmune thyroid disease. This case of multiple autoimmune syndrome is a distinctive subgroup of autoimmune disorders that is increasingly recognized. Female hormone levels appeared to play a role in disease pathogenesis in this case. The patient was predicted to have a favourable prognosis due to the absence of major organ involvement. This case revealed an uncommon form of complex polyautoimmune phenomena and should prompt physicians to extend immunological screening, particularly for females with multiple illnesses.

• 出版日期2013-10
• 单位大连医科大学