Arabidopsis Zinc Ribbon 3 is the ortholog of yeast mitochondrial HSP70 escort protein HEP1 and belongs to an ancient protein family in mitochondria and plastids

作者：Kluth Jantjeline; Schmidt Annika; Maerz Manuela; Krupinska Karin; Lorbiecke Rene^*

来源：FEBS Letters, 2012, 586(19): 3071-3076.

DOI：10.1016/j.febslet.2012.07.052

• Mitochondria
• Protein import
• Chaperone
• HSP
• ETCHED1
• ZIM17/TIM15

ZR proteins belong to a phylogenetically conserved family of small zinc-ribbon proteins in plastids and mitochondria of higher plants. The function of these proteins is so far unclear. The mitochondrial proteins share sequence similarities with mitochondrial Hsp70 escort proteins (HEP) from Saccharomyces cerevisiae (HEP1) and human. Expression of the mitochondrial ZR protein from Arabidopsis, ZR3, rescued a hep1 knockout mutant from yeast. Accordingly, ZR3 was found to physically interact with mitochondrial Hsp70 from Arabidopsis. Our findings support the idea that mitochondrial and plastidic ZR proteins from higher plants are orthologs of HEP proteins. %26lt;br%26gt;Structured summary of protein interactions: %26lt;br%26gt;ZR3 physically interacts with mtHSC70-2 by pull down (View i

• 出版日期2012-9-21