Nutritional predictors of mortality after discharge in elderly patients on a medical ward

作者：Buscemi Silvio^*; Batsis John A; Parrinello Gaspare; Massenti Fatima M; Rosafio Giuseppe; Sciascia Vittoria; Costa Flavia; Addario Sebastiano Pollina; Mendola Serena; Barile Anna M; Maniaci Vincenza; Rini Nadia; Caimi Gregorio

来源：European Journal of Clinical Investigation, 2016, 46(7): 609-618.

DOI：10.1111/eci.12637

• Bioimpedance
• hospitalization
• malnutrition
• mini-nutritional assessment
• mortality
• phase angle

BackgroundMalnutrition in elderly inpatients hospitalized on medical wards is a significant public health concern. The aim of this study was to investigate nutritional markers as mortality predictors following discharge in hospitalized medical elderly patients.
Materials and methodsThis is a prospective observational cohort study with follow-up of 48 months. Two hundred and twenty-five individuals aged 60 and older admitted from the hospital emergency room in the past 48 h were investigated at the medical ward in the University hospital in Palermo (Italy). Anthropometric and clinical measurements, Mini-nutritional Assessment (MNA) questionnaire, bioelectrical (BIA) phase angle (PA), grip strength were obtained all within 48 h of admission. Mortality data were verified by means of mortality registry and analysed using Cox-proportional hazard models.
ResultsNinety (40%) participants died at the end of follow-up. There were significant relationships between PA, MNA score, age and gender on mortality. Patients in the lowest tertile of PA (< 46 degrees) had higher mortality estimates [I vs II tertile: hazard ratio (HR) = 340; 95% confidence interval (CI): 201-577; II vs III tertile: HR = 383; 95% CI: 221-664; log-rank test: (2) = 436; P < 0001]. Similarly, the survival curves demonstrated low MNA scores (< 22) were associated with higher mortality estimates (HR = 185; 95% CI: 122-281 (2) = 82; P = 0004).
ConclusionsThe MNA and BIA-derived phase angle are reasonable tools to identify malnourished patients at high mortality risk and may represent useful markers in intervention trials in this high-risk subgroup.

• 出版日期2016-7