A QTL for Genotype by Sex Interaction for Anthropometric Measurements in Alaskan Eskimos (GOCADAN Study) on Chromosome 19q12-13

作者：Voruganti V Saroja^*; Diego Vincent P; Haack Karin; Cole Shelley A; Blangero John; Goering Harald H H; Laston Sandra; Wenger Charlotte R; Ebbesson Sven O E; Fabsitz Richard R; Devereux Richard B; Howard Barbara V; Umans Jason G; MacCluer Jean W; Comuzzie Anthony G

来源：Obesity, 2011, 19(9): 1840-1846.

DOI：10.1038/oby.2011.78

Variation in anthropometric measurements due to sexual dimorphism can be the result of genotype by sex interactions (GxS). The purpose of this study was to examine the sex-specific genetic architecture in anthropometric measurements in Alaskan Eskimos from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Maximum likelihood-based variance components decomposition methods, implemented in SOLAR, were used for GxS analyses. Anthropometric measurements included BMI, waist circumference (WC), waist/height ratio, percent body fat (%BF), and subscapular and triceps skinfolds. Except for WC, mean values of all phenotypes were significantly different in men and women (P < 0.05). All anthropometric measures were significantly heritable (P < 0.001). In a preliminary analysis not allowing for GxS interaction, evidence of linkage was detected between markers D19S414 and D19S220 on chromosome 19 for WC (logarithm of odds (lod) = 3.5), %BF (lod = 1.7), BMI (lod = 2.4), waist/height ratio (lod = 2.5), subscapular (lod = 2.1), and triceps skinfolds (lod = 1.9). In subsequent analyses which allowed for GxS interaction, linkage was again found between these traits and the same two markers on chromosome 19 with significantly improved lod scores for: WC (lod = 4.5), %BF (lod = 3.8), BMI (lod = 3.5), waist/height ratio (lod = 3.2), subscapular (lod = 3.0), and triceps skinfolds (lod = 2.9). These results support the evidence of a GxS interaction in the expression of genetic effects resulting in sexual dimorphism in anthropometric phenotypes and identify the chromosome 19q12-13 region as important for adiposity-related traits in Alaskan Eskimos.

• 出版日期2011-9