The "Tricky Business" of Identifying Mechanisms of Resistance to Anti-PD-1

作者:Wilmott James S; Rizos Helen; Scolyer Richard A; Long Georgina V*
来源:Clinical Cancer Research, 2017, 23(12): 2921-2923.
DOI:10.1158/1078-0432.CCR-17-0669

摘要

Resistance to immune checkpoint inhibitors can vary between patients and among metastases. Understanding the genomic, transcriptomic, and microenvironmental factors that contribute to this variability will reveal the mechanisms that tumors utilize to evade the therapeutic effects of checkpoint inhibitor immunotherapies and will enable us to develop strategies to overcome them.

  • 出版日期2017-6-15