Analysis of connection networks among miRNAs differentially expressed in early gastric cancer for disclosing some biological features of disease development

作者：Li, Boyu; Rao, Nini^*; Liu, Dingyu; Yang, Yang; Liu, Dingyun; Li, Yi; Liu, Hanming; Gan, Tao; Ding, Hui; Lin, Hao

来源：Gene, 2014, 548(2): 159-165.

DOI：10.1016/j.gene.2014.07.015

• Early gastric cancer
• Differentially expressed miRNAs
• Relevant connection network
• Biological features

This paper first identified differentially expressed miRNAs associated with early gastric cancer and then respectively constructed relevant connection networks among the identified differentially expressed miRNAs that corresponded to early gastric cancer and control tissues. Twenty-three differentially expressed miRNAs were identified, 18 of which were different with the related results on the same data, and they provide great discriminatory power between patients and controls. There are not only conserved unchangeable sub-networks but also different sub-networks between the two connection networks. From the consistency and differences between two connection networks, we disclosed several new biological features that promote early gastric cancer development. This study shows 23 miRNAs that are early gastric cancer-specific and are worthy to do further experimental studies. The revealed biological features for early gastric cancer will provide new insights into improved understanding of the molecular mechanisms of this disease.

• 出版日期2014-9-15
• 单位四川大学; 电子科技大学