Vitamin D receptor activation: cardiovascular and renal implications

作者：Nigwekar Sagar U^*; Thadhani Ravi

来源：Kidney International Supplements, 2013, 3(5): 427-430.

DOI：10.1038/kisup.2013.89

• chronic kidney disease
• end-stage renal disease
• hypertension
• left ventricular hypertrophy
• vitamin D
• vitamin D-binding protein

The effects of vitamin D receptor activation on cardiovascular diseases, especially hypertension and cardiac dysfunction, are areas of active investigation. This article reviews the current state of knowledge about vitamin D receptor activation with respect to blood pressure, heart, and vascular health, as well as to chronic kidney disease and end-stage renal disease. Potential biological mechanisms, the role of vitamin D-binding protein, and data from observational and randomized controlled trials on this topic are summarized.

• 出版日期2013-12