Association Between White Matter Hyperintensity and Lacunar Infarction on MRI and Subitem Scores of the Japanese Version of Mini-Mental State Examination for Testing Cognitive Decline: The Ohasama Study

作者：Elnimr Eman M; Kondo Takeo^*; Suzukamo Yoshimi; Satoh Michihiro; Oouchida Yutaka; Hara Azusa; Ohkubo Takayoshi; Kikuya Masahiro; Hirano Mikio; Hosokawa Aya; Hosokawa Toru; Imai Yutaka; Izumi Shin Ichi

来源：Clinical and Experimental Hypertension, 2012, 34(8): 541-547.

DOI：10.3109/10641963.2012.681723

• cognitive function
• silent cerebrovascular lesions
• stroke
• general population
• white matter hyperintensity
• lacunar infarction

We assessed whether subitem scores on the Mini-Mental State Examination (MMSE) associated independently with cerebral white matter hyperintensity (WMH) and lacunar infarction (LI). Magnetic resonance imaging (MRI) and neuropsychological evaluation (MMSE) were performed in 1008 elderly individuals from the Ohasama Study (348 men, 660 women [65.5%]; age 68.0 +/- 6.0 [mean +/- SD] years; MMSE score, 26.5 +/- 2.9). The relationships between MRI findings and MMSE subitem scores were analyzed by logistic regression. Significant associations were observed between the MMSE subitems "Orientation to place" and WMH, and "Copy a figure" and LI. Pathological changes were detected by brain MRI associated with a decrease in cognitive function in healthy elderly individuals.

• 出版日期2012