Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery

作者:Blazkova Iva; Hoai Viet Nguyen; Dostalova Simona; Kopel Pavel; Stanisavljevic Maja; Vaculovicova Marketa; Stiborova Marie; Eckschlager Tomas; Kizek Rene; Adam Vojtech*
来源:International Journal of Molecular Sciences, 2013, 14(7): 13391-13402.
DOI:10.3390/ijms140713391

摘要

Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.

  • 出版日期2013-7