Antitumor Properties of Modified Detonation Nanodiamonds and Sorbed Doxorubicin on the Model of Ehrlich Ascites Carcinoma

作者：Medvedeva N N; Zhukov E L^*; Inzhevatkin E V; Bezzabotnov V E

来源：Bulletin of Experimental Biology and Medicine, 2016, 160(3): 372-375.

DOI：10.1007/s10517-016-3174-z

• nanodiamonds
• doxorubicin
• Ehrlich ascites carcinoma

We studied antitumor properties of modified detonation nanodiamonds loaded with doxorubicin on in vivo model of Ehrlich ascites carcinoma. The type of tumor development and morphological characteristics of the liver, kidneys, and spleen were evaluated in experimental animals. Modified nanodiamonds injected intraperitoneally produced no antitumor effect on Ehrlich carcinoma. However, doxorubicin did not lose antitumor activity after sorption on modified nanodiamonds.

• 出版日期2016-1