Novel 3-(2-Oxo-2H-benzo[b][1,4]oxazin-3-yl)propanoates from Dimethyl-2-oxoglutarate and Test of Their Biological Activity

作者：Hachama Kamel; Khodja Mohamed^*; Moulay Saad; Boutoumi Hocine; Hennig Lothar; Sicker Dieter

来源：Journal of Heterocyclic Chemistry, 2013, 50(2): 413-416.

DOI：10.1002/jhet.1520

Five novel 3-(2-oxo-2H-benzo[b][1,4]oxazin-3-yl)propanoates were synthesized under mild conditions from 2-aminophenols and dimethyl-2-oxoglutarate. Biological assays of these 1,4-benzoxazinones were conducted with three bacterial strains and one yeast. All compounds were active against a Candida albicans ATCC 10231, whereas only methyl 3-(6-methyl-2-oxo-2H-benzo[b][1,4]oxazin-3-yl)propanoate showed a general moderate activity against the bacterial strains tested.

• 出版日期2013-3