科研之友
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摘要
The growing prevalence of cardiovascular diseases leads to the increasing need for vascular patches. In this work, we prepared a polyurethane/polyurethane-sodium triphosphate (PU/PU-STPP) nanoparticle composite film and subsequently a PU/PU-STPP/decellularized scaffold vascular patch (PSVP) using a simple and low-cost method-cosedimentation. The PU/PU-STPP nanoparticle composite film exhibited the improved blood and cell compatibilities, reduced platelet adhesion, and enhanced cell attachment and proliferation. Furthermore, we explored the performance of PSVP in vivo, using a murine model. Thirty days after the implantation with PSVP, the patched abdominal artery maintained patency, and the formation of endothelial tissue, e.g., endothelialization was observed, demonstrating its potential in vascular repair and regeneration. Moreover, our data showed that the material had the surface similar to the luminal surface of a blood vessel, and this similarity and the synergetic effect of PU-STPP nanoparticles significantly improved the blood and cell compatibilities of the material, effectively inhibited platelet adhesion and enhanced cell attachment, thus promoting endothelialization. To sum up, these findings implied that the PSVP may be used as a promising vascular patch material.
