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An 1,2-Elimination Approach to the Enantioselective Synthesis of 1,3-Disubstituted Linear Allenes
Zhang Yan
Hao Hong Dong
Wu Yikang
Synlett, 2010, (6): 905-908.
The construction of 1,3-disubstituted allene skeleton, which is present in many natural allenes, via an i-PrMgBr-mediated elimination of optically active 3-acetoxy-2-iodo-prop-1-ene derviatives is exemplified through the enantioselective total synthesis of two bioactive natural allenes.
alkynes; carbanions; elimination; halides; natural products
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