Phytochemicals from Cunninghamia konishii Hayata Act as Antifungal Agents

作者：Cheng Sen Sung^*; Chung Min Jay; Lin Chun Ya; Wang Ya Nan; Chang Shang Tzen

来源：Journal of Agricultural and Food Chemistry, 2012, 60(1): 124-128.

DOI：10.1021/jf2042196

• Cunninghamia konishii
• wood
• extract
• fungi
• antifungal activity

The aims of the present study were to isolate and identify the antifungal compounds from the ethanolic extract of Cunninghamia konishii wood and to evaluate their antifungal activities against wood decay fungi. The results showed that the n-Hex soluble fraction of the ethanolic extract from C. konishii wood had an excellent inhibitory effect against Lenzites betulina, Trametes versicolor, Laetiporus sulphureus, and Gloeophyllum trabeum, with IC(50) values of 33, 46, 62, and 49 mu g/mL, respectively. By following the bioactivity-guided fractionation procedure, four sesquiterpenes, T-cadinol, cedrol, T-muurolol, and (-)-epicedrol, and three diterpenes, 13-epi-manool, cis-abienol, and isoabienol, were identified from the active subfractions. Among the main constituents of the ethanolic extract from C. konishii, T-cadinol, cedrol, and T-muurolol efficiently inhibited the growth of four wood-rot fungi at the concentration of 100 mu g/mL, with antifungal indices of 51.4-100.0%, 68.3-100.0%, and 39.5-100.0%, respectively. Results of this study show that the ethanolic extract of C. konishii wood may be considered as a potent source of T-cadinol, cedrol, and T-muurolol as new natural antifungal agents.

• 出版日期2012-1-11