Detection and molecular characterization of human cosavirus in a pediatric patient with acute gastroenteritis, Japan

作者：Okitsu Shoko^*; Khamrin Pattara; Thongprachum Aksara; Nishimura Shuichi; Kalesaran Angela F C; Takanashi Sayaka; Shimizu Hiroyuki; Hayakawa Satoshi; Mizuguchi Masashi; Ushijima Hiroshi

来源：Infection, Genetics and Evolution, 2014, 28: 125-129.

DOI：10.1016/j.meegid.2014.09.019

• Child
• Diarrhea
• Genotype
• Human cosavirus
• Japan

Human cosavirus (HCoSV) is a genus recently identified in the family Picornaviridae, which includes important pathogens in human health. The pathogenicity of HCoSV remains unclear. This study reports that an HCoSV strain, 10928/2012/JPN, was identified and collected from the stool sample of a child with acute gastroenteritis in Japan, with the detection rate of 0.16%. The patient was not co-infected with other common diarrhea-causal viruses, suggesting HCoSV as a causal pathogen in this pediatric patient. Phylogenetic and sequence analyses exhibited that the virus strain was classified as a new genotype in HCoSV A species, and this study is first to detect HCoSV in a clinical specimen collected in Japan. These results showed that surveillance of HCoSV is important for detecting viral agents in children with diarrhea, despite being the low detection rate.

• 出版日期2014-12