Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle

作者:Murata Kazuya; Nakao Kikuyo; Hirata Noriko; Namba Kensuke; Nomi Takao; Kitamura Yoshihisa; Moriyama Kenzo; Shintani Takahiro; Iinuma Munekazu; Matsuda Hideaki*
来源:Journal of Natural Medicines, 2009, 63(3): 355-359.
DOI:10.1007/s11418-009-0331-y

摘要

The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.

  • 出版日期2009-7