An expeditious approach to access 2-arylimidazo[1,2-a]pyridin-3-ol from 2-amino pyridine through a novel Petasis based cascade reaction

作者：Wang Yuanxiang; Saha Biswajit; Li Fang; Frett Brendan; Li Hong yu^*

来源：Tetrahedron Letters, 2014, 55(7): 1281-1284.

DOI：10.1016/j.tetlet.2013.12.018

• Cascade reaction
• Petasis reaction
• MCR
• 2-Arylimidazo[1,2-a]pyridine-3-ol

An expeditious cascade protocol for the synthesis of functionalized imidazo[1,2-a]pyridin-3-ols was developed based on the Petasis reaction. With the availability of commercial reagents and high efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of imidazo-pyridin-3-ol analogues.

• 出版日期2014-2-12