Leucyl-tRNA synthetase: double duty in amino acid sensing

作者:Duran Raul V; Hall Michael N*
来源:Cell Research, 2012, 22(8): 1207-1209.
DOI:10.1038/cr.2012.68

摘要

The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.

  • 出版日期2012-8