Assessment of Biochemical Profiles in Premenopausal and Postmenopausal Women with Breast Cancer

作者：Yadav Naval Kishor^*; Poudel Bibek; Thanpari C; Koner Bidhan Chandra

来源：Asian Pacific Journal of Cancer Prevention, 2012, 13(7): 3385-3388.

DOI：10.7314/APJCP.2012.13.7.3385

• Breast cancer
• premenopausal
• postmenopausal
• Nepal

Objective: The study was conducted to assess biochemical profiles in premenopausal and postmenopausal women having breast cancer. Materials and Methods: A hospital based case control study was carried out at Manipal Teaching Hospital (MTH), Pokhara, Nepal. The analysed variables were age, metabolic profile including total cholesterol, triglycerides, HDL-C, LDL-C, blood sugar, insulin concentration, C-peptide, HbA1c and selenium. Descriptive statistics and testing of hypothesis were used for the analysis using EPI INFO and SPSS 16 software. Results: In premenopausal women, significant differences were noted for total cholesterol (P value < 0.001), triglycerides (P value 0.002), HbA1c level (P value < 0.001), insulin concentration (P value 0.030), C-peptide concentration (P value 0.001), and selenium (P value < 0.001) between cases and controls. Insignificant results were found for HDL-C (P value 0.749), LDL-C (P value 0.933), blood sugar (P value 0.59) and BMI (P value 0.746). Similarly, significant difference in total cholesterol (P value < 0.001), triglycerides (P value 0.001), LDL-C (P value < 0.001), HDL-C (P value 0.025), blood sugar (P value < 0.001), insulin concentration (P value < 0.001), c-peptide concentration (P value < 0.001), HbA1c level (P value < 0.001) and selenium (P value < 0.001) were observed for postmenopausal patients and controls. Conclusions: Assessing metabolic changes and their management may be important for control of breast cancer and increased survival.

• 出版日期2012