Amide Formation Using In Situ Activation of Carboxylic Acids with [Et2NSF2]BF4

作者：Mahe Olivier; Desroches Justine; Paquin Jean Francois^*

来源：European Journal of Organic Chemistry, 2013, 2013(20): 4325-4331.

DOI：10.1002/ejoc.201300289

• Synthetic methods
• Amides
• Carboxylic acids
• Amines
• Borates

%26lt;title content-type=%26quot;main%26quot;%26gt;Abstract %26lt;br%26gt;The formation of amides through the in situ activation of carboxylic acids with [Et2NSF2]BF4 is presented. A wide range of carboxylic acids and amines were used to produce the corresponding amides in up to 99% yield. The reaction of hindered amines was also possible in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under slightly modified conditions. An enantiopure carboxylic acid and amine were both shown to react without racemization.

• 出版日期2013-7