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摘要
A series of enantioselective pyrrolidine-2,4,4-tricarboxylate derivatives were synthesized by the [3+2] 1,3-dipolar cycloaddition of azomethine ylide with alkylidene malonates. By using 4mol% of a (CuN)-N-II,P oxazolinylferrocene ligand complex and 10mol% of a base, pyrrolidine analogues were obtained in high yields (77-99%) and excellent enantioselectivities (up to 99% ee).
- 出版日期2015-4
- 单位北京理工大学
