Multiple Nucleotide Substitutions in the Neisseria meningitidis Serogroup C ctrA Gene Cause False-Negative Detection by Real-Time PCR

作者:Cavrini Francesca; Liguori Giovanna; Andreoli Arianna; Sambri Vittorio*
来源:Journal of Clinical Microbiology, 2010, 48(8): 3016-3018.
DOI:10.1128/JCM.00103-10

摘要

Two strains of Neisseria meningitidis serogroup C with disparate sequences of ctrA were isolated. The nucleotide substitutions did not alter the corresponding protein sequences, but they impeded the detection of these meningococcal isolates by real-time PCR.

  • 出版日期2010-8