Docking proteins

作者:Brummer Tilman; Schmitz Peiffer Carsten; Daly Roger J*
来源:FEBS Journal, 2010, 277(21): 4356-4369.
DOI:10.1111/j.1742-4658.2010.07865.x

摘要

Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2-associated binder/Daughter of Sevenless, insulin receptor substrate, fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category. This minireview focuses on the structure, function and regulation of these proteins.