Dermal Pharmacokinetics of Terpinen-4-ol Following Topical Administration of Zingiber cassumunar (plai) Oil

作者：Chooluck Kotchaphan; Singh Rajendra P; Sathirakul Korbtham; Derendorf Hartmut^*

来源：Planta Medica, 2012, 78(16): 1761-1766.

DOI：10.1055/s-0032-1315262

• terpinen-4-ol
• Zingiber cassumunar
• Zingiberaceae
• plai oil
• dermal pharmacokinetics
• microdialysis

The purpose of this study was to investigate dermal pharmacokinetics of terpinen-4-ol in rats following topical administration of plai oil derived from the rhizomes of Zingiber cassumunar Roxb. Unbound terpinen-4-ol concentrations in dermal tissue were measured by microdialysis. The dermal pharmacokinetic study of terpinen-4-ol was performed under non-occlusive conditions. The oil was topically applied at a dose of 2, 4, and 8 mg/cm(2) plai oil corresponding to the amount of 1.0, 1.9, and 3.8 mg/cm(2) terpinen-4-ol, respectively. Following topical application of the oil, terpinen-4-ol rapidly distributed into the dermis and demonstrated linear pharmacokinetics with no changes in the dose-normalized area under the concentration-time curves across the investigated dosage range. The mean percentages of free terpinen-4-ol distributed in the dermis per amount of administered were 0.39 +/- 0.06%, 0.41 +/- 0.08%, and 0.30 +/- 0.03% for 2, 4, and 8 mg/cm(2) doses, respectively. The dermal pharmacokinetics of terpinen-4-ol could provide information for its further formulation development and therapy schedules.

• 出版日期2012-11