An anti-interferon activity shared by paramyxovirus C proteins: Inhibition of Toll-like receptor 7/9-dependent alpha interferon induction

作者：Yamaguchi Mayu; Kitagawa Yoshinori; Zhou Min; Itoh Masae; Gotoh Bin^*

来源：FEBS Letters, 2014, 588(1): 28-34.

DOI：10.1016/j.febslet.2013.11.015

• Paramyxovirus
• C protein
• TLR7
• Interferon-alpha
• pDC

Paramyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. To identify its unknown anti-IFN activity, we examined the effect of Sendai virus C protein on activation of the IFN-alpha promoter via various signaling pathways. This study uncovers a novel ability of C protein to block Toll-like receptor (TLR) 7-and TLR9-dependent IFN-alpha induction, which is specific to plasmacytoid dendritic cells. C protein interacts with a serine/threonine kinase IKK alpha and inhibits phosphorylation of IRF7. This anti-IFN activity of C protein is shared across genera of the Paramyxovirinae, and thus appears to play an important role in paramyxovirus immune evasion.
Structured summary of protein interactions:
SeV C physically interacts with IKKalpha by anti tag coimmunoprecipitation (View interaction)
bPIV3 C physically interacts with IKKalpha by anti tag coimmunoprecipitation (1, 2)
NiV C physically interacts with IKKalpha by anti tag coimmunoprecipitation (1

• 出版日期2014-1-3