Systemic antifungal therapy for tinea capitis in children: An abridged Cochrane Review

作者：Chen, Xiaomei; Jiang, Xia; Yang, Ming; Bennett, Cathy; Gonzalez, Urba; Lin, Xiufang; Hua, Xia; Xue, Siliang; Zhang, Min^*

来源：Journal of the American Academy of Dermatology, 2017, 76(2): 368-374.

DOI：10.1016/j.jaad.2016.08.061

• children
• Cochrane
• systemic antifungal therapy
• systematic review
• tinea capitis
• treatment

Background: The comparative efficacy and safety profiles of systemic antifungal drugs for tinea capitis in children remain unclear. @@@ Objective: We sought to assess the effects of systemic antifungal drugs for tinea capitis in children. @@@ Methods: We used standard Cochrane methodological procedures. @@@ Results: We included 25 randomized controlled trials with 4449 participants. Terbinafine and griseofulvin had similar effects for children with mixed Trichophyton and Microsporum infections ( risk ratio 1.08, 95% confidence interval 0.94-1.24). Terbinafine was better than griseofulvin for complete cure of T tonsurans infections ( risk ratio 1.47, 95% confidence interval 1.22-1.77); griseofulvin was better than terbinafine for complete cure of infections caused solely by Microsporum species ( risk ratio 0.68, 95% confidence interval 0.53-0.86). Compared with griseofulvin or terbinafine, itraconazole and fluconazole had similar effects against Trichophyton infections. @@@ Limitations: All included studies were at unclear or high risk of bias. Lower quality evidence resulted in a lower confidence in the estimate of effect. Significant clinical heterogeneity existed across studies. @@@ Conclusions: Griseofulvin or terbinafine are both effective; terbinafine is more effective for T tonsurans and griseofulvin for M canis infections. Itraconazole and fluconazole are alternative but not optimal choices for Trichophyton infections. Optimal regimens of antifungal agents need further studies.

• 出版日期2017-2
• 单位四川大学