An Ugi Reaction Incorporating a Redox-Neutral Amine C-H Functionalization Step

作者:Zhu Zhengbo; Seidel Daniel
来源:Organic Letters, 2016, 18(4): 631-633.
DOI:10.1021/acs.orglett.5b03529

摘要

Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral alpha-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides. Reactions are promoted by acetic acid and represent a new variant of the Ugi reaction.

  • 出版日期2016-2-19