An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus

作者：Jiang Meiyan; Steyger Peter S^*

来源：Expert Opinion on Therapeutic Patents, 2015, 25(11): 1349-1352.

DOI：10.1517/13543776.2015.1076392

• clinical therapy
• diabetes
• dioxa-bicyclo[3
• 2
• 1]octane-2
• 3
• 4-triol derivatives
• ertugliflozin
• inhibitors
• PF-04971729
• sodium-glucose linked co-transporter
• type 2 diabetes mellitus

Introduction: Type 2 diabetes mellitus (T2DM) is a growing and serious global health problem. Pharmacological inhibition of the sodium-glucose cotransporter-2 (SGLT2; SLC5A2) increases urinary glucose excretion, decreasing plasma glucose levels in an insulin-independent manner. Agents that inhibit SGLT2 have recently become available for clinical therapy of T2DM.Areas covered: The patent claims a new class of SGLT2 inhibitors: derivatives of dioxa-bicyclo[3.2.1]octane-2,3,4-triol (including ertugliflozin; PF-04971729). The invention describes the design, synthesis and pharmacological tests related to ertugliflozin, which could ultimately lead to efficacious therapy for T2DM alone or in combination with other anti-diabetic agents.Expert opinion: Ertugliflozin is likely to be of great clinical significance in the near future. Continued analysis of ertugliflozin derivatives to now validate safe and efficacious treatment of T2DM in a larger number of clinical subjects over an extended period is needed to further support clinical utility. Identification, and discussion, of likely contra-indications is also needed.

• 出版日期2015-11-2