A mathematical algorithm for detection of Late-onset Sepsis in very-low birth weight infants: A preliminary diagnostic test evaluation

作者：Gur Ilan; Markel Gal; Nave Yaron; Vainshtein Igor; Eisenkraft Arik; Riskin Arieh^*

来源：Indian Pediatrics, 2014, 51(8): 647-650.

DOI：10.1007/s13312-014-0469-x

• Algorithm
• Neonatal sepsis
• Preterm infants
• Very low birth weight

To study the diagnostic ability of RALIS (computerized mathematical algorithm and continuous monitoring device) to detect late onset sepsis among very low birth weight preterm neonates.
Randomly chosen 24 very low birth weight infants with proven sepsis were compared to 22 infants without sepsis. The clinical parameters were retrospectively collected from the medical records. The ability of RALIS to detect late onset sepsis was calculated.
RALIS positively identified 23 of the 24 infants with sepsis (sensitivity 95.8%). It indicated sepsis alert median 2.0 days earlier than clinical suspicion. A false positive alert was indicated in 23% (5/22) infants. The specificity, and positive and negative predictive ability of RALIS were 77.3%. 82.1% and 94.4%, respectively.
RALIS may aid in the early diagnosis of late onset sepsis in very low birth weight preterm infants.

• 出版日期2014-8