Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation

作者：Kano Taichi; Kumano Takeshi; Sakamoto Ryu; Maruoka Keiji^*

来源：Organic and Biomolecular Chemistry, 2013, 11(2): 271-278.

DOI：10.1039/c2ob26778k

An asymmetric synthesis of cyclic amino acids having piperidine and azepane core structures was realized starting from readily available glycine and alanine esters by combination of phase-transfer catalyzed asymmetric alkylation and subsequent reductive amination.

• 出版日期2013