APOE Moderates the Association between Lifestyle Activities and Cognitive Performance: Evidence of Genetic Plasticity in Aging

作者：Runge Shannon K^*; Small Brent J; McFall G Peggy; Dixon Roger A

来源：Journal of the International Neuropsychological Society, 2014, 20(5): 478-486.

DOI：10.1017/S1355617714000356

• Apolipoprotein epsilon 4
• Genotype
• Genotype-phenotype correlation
• Cognition
• Lifestyle
• Victoria Longitudinal Study

The current study examined independent and interactive effects between Apolipoprotein E (APOE) genotype and two types of cognitively-stimulating lifestyle activities (CSLA)-integrated information processing (CSLA-II) and novel information processing (CSLA-NI)-on concurrent and longitudinal changes in cognition. Three-wave data across 6 years of follow-up from the Victoria Longitudinal Study (n = 278; ages 55-94) and linear mixed model analyses were used to characterize the effects of APOE genotype and participation in CSLA-II and CSLA-NI in four cognitive domains. Significant CSLA effects on cognition were observed. More frequent participation in challenging activities (i.e., CSLA-NI) was associated with higher baseline scores on word recall, fact recall, vocabulary and verbal fluency. Conversely, higher participation in less cognitively-challenging activities (i.e., CSLA-II) was associated with lower scores on fact recall and verbal fluency. No longitudinal CSLA-cognition effects were found. Two significant genetic effects were observed. First, APOE moderated CSLA-II and CSLA-NI associations with baseline verbal fluency and fact recall scores. Second, APOE non-epsilon 4 earners%26apos; baseline performance were more likely to be moderated by CSLA participation, compared to APOE-epsilon 4 carriers. Our findings suggest APOE may be a %26quot;plasticity%26quot; gene that makes individuals more or less amenable to the influence of protective factors such as CSLA.

• 出版日期2014-5