Markers of malnutrition after intestinal transplantation: the role of IGF-1 and calprotectin

作者：Vrakas Georgios^*; O'Connor Marion; Matsou Artemis; Arantes Rubens Macedo; Friend Peter; Reddy Srikanth; Vaidya Anil

来源：Journal of Clinical Biochemistry and Nutrition, 2015, 56(1): 64-65.

DOI：10.3164/jcbn.14-14

• IGF-1
• calprotectin
• intestinal transplantation
• nutritional status

The objective of this study is to valuate two biomarkers that may guide nutritional assessment during follow up after intestinal transplantation. We performed a retrospective study on prospectively collected data of insulin-like growth factor-1 (IGF-1) and effluent calprotectin in patients undergoing intestinal transplantation. Optimal nutritional status (ONS) was defined by using the Malnutrition Universal Screening Tool (MUST). IGF-1 and calprotectin were correlated with ONS by Pearson correlation. Eighteen cadaveric intestinal transplants were performed over 1,650 days (median follow up 425 days, range 29-1,650 days). Mean IGF-1 and calprotectin were significantly associated with independent nutrition. Seven patients became malnourished on one or more occasions. During malnutrition the mean IGF-1 was 22 +/- 14 ng/ml and calprotectin 1,597 +/- 1,055 mcg/g. Mean weight during episodes of malnutrition changed from 64.77 +/- 8.76 kg to 59.05 +/- 8.5 kg (-8.9 +/- 1.25%). Both IGF-1 and calprotectin negatively correlated with ONS (Pearson's r, -0.612, p = 0.014). Patients broadly aligned with three groups: nutritionally replete (normal IGF-1 and normal calprotectin), nutritionally equivocal (normal or low normal IGF-1 and high calprotectin), and malnourished (low IGF-1 and high calprotectin). Patients with low IGF-1 and high calprotectin may have a benign clinical presentation. However it is in their interests to have parenteral nutrition restarted pending further investigation.

• 出版日期2015-1-1