Central B-Cell Tolerance: Where Selection Begins

作者：Pelanda Roberta^*; Torres Raul M

来源：Cold Spring Harbor Perspectives in Biology, 2012, 4(4): a007146.

DOI：10.1101/cshperspect.a007146

The development of an adaptive immune system based on the random generation of antigen receptors requires a stringent selection process that sifts through receptor specificities to remove those reacting with self-antigens. In the B-cell lineage, this selection process is first applied to IgM(+) immature B cells. By using increasingly sophisticated mouse models, investigators have identified the central tolerance mechanisms that negatively select autoreactive immature B cells and prevent inclusion of their antigen receptors into the peripheral B-cell pool. Additional studies have uncovered mechanisms that promote the differentiation of nonautoreactive immature B cells and their positive selection into the peripheral B-cell population. These mechanisms of central selection are fundamental to the generation of a naive B-cell repertoire that is largely devoid of self-reactivity while capable of reacting with any foreign insult.

• 出版日期2012-4