科研之友
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摘要
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a negative regulator of the oncogenic P13-K/Akt signaling pathway. Loss-of-function mutations of PTEN are seen in several human solid cancers. A murine model of conditional Pten inactivation in the pancreas is described that leads to acquisition of a profound metaplastic ductal phenotype accompanied by loss of differentiated acinar units. Evidence is presented for a centroacinar cell origin of the metaplastic "neoductules." These mice also develop invasive pancreatic adenocarcinomas at a low frequency, and provide a unique in vivo platform for exploring the role of P13-K/Akt signaling in pancreatic neoplasia.
- 出版日期2005-9
