Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

作者:Changeux JP*; Edelstein SJ
来源:Current Opinion in Neurobiology, 2001, 11(3): 369-377.
DOI:10.1016/S0959-4388(00)00221-X

摘要

Recent chemical and advanced structural studies on site-directed and naturally occurring pathological mutants of individual members of the multigene family of nicotinic acetylcholine receptors have yielded structure-function relationships supporting indirect 'allosteric' interactions between the acetylcholine-binding sites and the ion channel in signal transduction.

  • 出版日期2001-6