科研之友
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摘要
Background & Aim: Hyperhomocysteinemia is a cardiovascular risk factor even among children Supplementation or oral folic acid may reduce homocysteine levels to normal However, data is limited at this point for healthy children and adolescents
Methods: Five hundre and twenty lour children participated in the study, Twenty six of them were found to be hyperhomocysteinemic (>95(th) percentile for age) Twenty of them received 5 mg of folic acid twice per week for two consecutive months while the other six received a diet rich in dietary folate
Results: Serum homocysteine levels were statistically significantly decreased from 13 1 (10-24 2 mu mon) to 7 7 (4 9-15.2 mu mol/L.), p<0 001 Serum fblate levels were significantly rose from 4 3 (3-20 ng/mL) to 16 8(7-20 ng/mL), p<0 001 On the contrary, no important changes were observed in the above parameters in children to whom a diet rich in folic acid was recommended Homocysteine levels were found to be positively associated with age (r=0 314, p<0 (101), BMI (r=0 192, p<0 001), WC (r = 0 215, p<0 001). simple sugars (r= 0 182, p<0 001) and negatively associated with folic acid (r = -0.331, p<0.001), vitamin 1312 (r = -0 214, p<0 001) and dietary folic acid (r= -0 228, p=0 003)
Conclusions: Oral folic acid 5 mu twice per week may efficiently reduce serum homocysteine levels and increase serum folic acid levels in healthy children with increased homocysteine levels (>95(th) percentile for age) Hyperhomocystememia in childhood may be a predictive factor of cardiovascular disease In addition, these results may offer more help to health practioners in order to establish more prospective studies to elucidate the relationship between homocysteme, folic acid and heart disease in children Hippokr atm 2010, 14 (2) 105-108
- 出版日期2010-6
