Apoptosis in chronic cutaneous lupus erythematosus, discoid lupus, and lupus profundus

作者：Ileana Saenz Corral Claudia; Elisa Vega Memije Maria; Martinez Luna Eduwiges; Carlos Cuevos Gonzalez Juan; Angelica Rodriguez Carreon Alma; Jose Bollain y Goytia de la Rosa Juan; de Jesus Torres del Muro Felipe; Avalos Diaz Esperanza

来源：International Journal of Clinical and Experimental Pathology, 2015, 8(6): 7260-7265.

• Apoptosis
• discoid lupus
• lupus profundus
• chronic cutaneous lupus erythematosus
• proapoptotic molecules

Introduction: Lupus erythematosus is a multisystemic disease that is characterized by autoantibody production and immune complex deposition in such tissues as the mucosa, joints, the central nervous system, and skin. Cutaneous lupus erythematosus is categorized as acute, subacute, and chronic. Chronic cutaneous lupus erythematosus comprises discoid lupus erythematosus (DLE) and lupus profundus (LP). Aim: To analyze the expression of proapoptotic molecules in patients with lupus erythematosus discoid and lupus profundus. Material and methods: Descriptive study, the study groups comprised 10 cases of LP and 10 cases of DLE, and a control. Skin samples of cases and controls were processed for immunohistochemistry and by TUNEL technique. The database and statistical analysis was performed (statistical test X-2) SPSS (Chicago, IL, USA). Results: Apoptotic features were broadly distributed along the skin biopsies in epidermal keratinocytes as well as at dermis. By immunohistochemistry the expression of Fas receptor and Fas-L was higher in the skin of lupus patients compared with controls. We also noted differences in Fas-L, -Fas, and -Bax proteins expression intensity in discoid lupus erythematosus patients in the epidermis, and hair follicles. Conclusions: Fas and Fas-L are expressed similarly in LP and DLE.

• 出版日期2015