Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections

作者：De Clercq Erik; Ferir Geoffrey; Kaptein Suzanne; Neyts Johan^*

来源：Viruses-Basel, 2010, 2(6): 1279-1305.

DOI：10.3390/v2061279

• antiviral therapy
• HBV therapy
• nucleoside analogs
• viral hepatitis

While 25 compounds have been formally licensed for the treatment of HIV infection (AIDS), only seven licensed products are currently available for the treatment of chronic hepatitis B virus (HBV) infection: interferon-alpha, pegylated interferon-alpha, lamivudine, adefovir (dipivoxil), entecavir, telbivudine and tenofovir (disoproxil fumarate). In contrast to the treatment of HIV infections where the individual drugs are routinely used in combination, for the treatment of chronic HBV infection the individual drugs are generally used in monotherapy. In principle, combination drug therapy should allow reducing the likelihood of drug-resistant development.

• 出版日期2010-6
• 单位河北医科大学