Uniting Anion Relay Chemistry with Pd-Mediated Cross Coupling: Design, Synthesis and Evaluation of Bifunctional Aryl and Vinyl Silane Linchpins

作者：Smith Amos B III^*; Kim Won Suk; Tong Rongbiao

来源：Organic Letters, 2010, 12(3): 588-591.

DOI：10.1021/ol902784q

Union of type II Anion Relay Chemistry (ARC) with Pd-induced Cross Coupling Reactions (CCR) has been achieved, in conjunction with the design, synthesis, and evaluation of a new class of bifunctional linchpins, comprising a series of vinyl silanes bearing beta- or gamma-electrophilic sites. The synthetic tactic permits both alkylation and Pd-medlated CCR of the anions derived via 1,4-silyl C(sp(2))-O Brook Rearrangements.

• 出版日期2010-2-5