Diagnostic value of IgG4 Indices in IgG4-Related Hypertrophic Pachymeningitis

作者：Della Torre Emanuel^*; Galli Laura; Franciotta Diego; Bozzolo Enrica Paola; Briani Chiara; Furlan Roberto; Roveri Luisa; Sessa Maria; Passerini Gabriella; Sabbadini Maria Grazia

来源：Journal of Neuroimmunology, 2014, 266(1-2): 82-86.

DOI：10.1016/j.jneuroim.2013.10.008

• IgG4
• IgG4-related disease
• IgG4-related pachymeningitis
• Hypertrophic pachymeningitis
• Pachymeningitis
• Cerebrospinal fluid

Diagnosis of IgG4-Related Hypertrophic Pachymeningitis (IgG4-HP) relies on meningeal biopsies, because cerebrospinal fluid (CSF) diagnostic biomarkers are lacking. Here, we determined whether IgG4 intrathecal production could distinguish IgG4-HP from other disorders presenting with HP (OHP). In patients with IgG4-HP, the median CSF IgG4 concentration, IgG4 Index and IgG4(Loc) were significantly higher than in both controls and OHP. CSF IgG4 levels higher than 2.27 mg/dL identified 100% of IgG4-HP and 5% of OHP. An IgG4(Loc) cut-off of 0.47 identified 100% of IgG4-HP and no cases of OHP. Our results support CSF IgG4 quantification and IgG4 Indices as alternatives to meningeal biopsy for the diagnosis of IgG4-HP when this procedure is contraindicated or uninformative.

• 出版日期2014-1-15