A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

作者：Leslie, Daniel C.; Waterhouse, Anna; Berthet, Julia B.; Valentin, Thomas M.; Watters, Alexander L.; Jain, Abhishek; Kim, Philseok; Hatton, Benjamin D.; Nedder, Arthur; Donovan, Kathryn; Super, Elana H.; Howell, Caitlin; Johnson, Christopher P.; Vu, Thy L.; Bolgen, Dana E.; Rifai, Sami; Hansen, Anne R.; Aizenberg, Michael; Super, Michael; Aizenberg, Joanna; Ingber, Donald E.^*

来源：Nature Biotechnology, 2014, 32(11): 1134-1140.

DOI：10.1038/nbt.3020

• CARDIOPULMONARY BYPASS CIRCUITS
• HEPARIN
• BIOCOMPATIBILITY
• ANTICOAGULATION
• HEMODIALYSIS
• PERFORMANCE
• OXYGEN
• PMEA

Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.

• 出版日期2014-11