Braking Bad: Blockade of Inhibitory Pathways Improves Interleukin-15 Therapy

作者:Carson William E III*
来源:Clinical Cancer Research, 2010, 16(24): 5917-5919.
DOI:10.1158/1078-0432.CCR-10-2658

摘要

Blockade of the CTLA-4 and PD-1 inhibitory pathways in T cells via the administration of neutralizing antibodies at the time of interleukin (IL)-15 therapy markedly enhanced the survival of tumor-bearing mice as compared with those receiving IL-15 alone or IL-15 in combination with just one of the antibodies. Clin Cancer Res; 16(24); 5917-9.

  • 出版日期2010-12-15

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