Diagnosis of cystic echinococcosis, central Peruvian highlands

作者：Gavidia Cesar M^*; Gonzalez Armando E; Zhang Wenbao; McManus Donald R; Lopera Luis; Ninaquispe Berenice; Garcia Hector H; Rodriguez Silvia; Verastegui Manuela; Calderon Carmen; Pan William K Y; Gilman Robert H

来源：Emerging Infectious Diseases, 2008, 14(2): 260-266.

DOI：10.3201/eid1402.061101

We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1 % and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.

• 出版日期2008-2
• 单位河北医科大学