Highly water soluble room temperature superionic liquids of APIs

作者：Carrera Goncalo V S M; Santos Miguel M; Costa Alexandra; Rebelo Luis Paulo N; Marrucho Isabel M; da Ponte M Nunes; Branco Luis C^*

来源：New Journal of Chemistry, 2017, 41(15): 6986-6990.

DOI：10.1039/c7nj01398a

Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by H-1 and C-13 NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.

• 出版日期2017-8-7