Pediatric Pseudotumor Cerebri Associated With Low Serum Levels of Vitamin A

作者：Dotan Gad^*; Goldstein Michaella; Stolovitch Chaim; Kesler Anat

来源：Journal of Child Neurology, 2013, 28(11): 1370-1377.

DOI：10.1177/0883073812474344

• pseudotumor cerebri
• intracranial hypertension
• vitamin A deficiency
• hypovitaminosis A
• malabsorption
• optic atrophy
• celiac disease

The aim of this study was to describe the association between pediatric pseudotumor cerebri and low serum vitamin A levels. We retrospectively reviewed the charts of 6 children (5 boys, 1 girl; mean age 8 years) with increased intracranial pressure and low serum vitamin A levels (mean 16.0 +/- 8.8 mu g/dL). The etiology of the vitamin A deficiency was a restricted diet (2 children), intestinal malabsorption caused by celiac disease (2 children), and undetermined cause (2 children). Only 1 child had ocular signs of xerosis. Poor visual acuity at presentation and lower serum vitamin A levels were associated with a poor visual outcome and development of optic atrophy. In conclusion, pseudotumor cerebri in children can be associated with vitamin A deficiency even when other manifestations of xerophthalmia do not exist. Early recognition of this condition and appropriate therapy can prevent blindness.

• 出版日期2013-11