Postbariatric Surgery Neuropathic Pain (PBSNP): Case Report, Literature Review, and Treatment Options

作者：Kai****m Vasanth Kattalai^*; DeCastro Claricio; Macaluso Claude; Kleiman Anne

来源：Pain Medicine, 2015, 16(2): 374-382.

DOI：10.1111/pme.12590

• Pain
• Neuralgia
• Bariatric Surgery Neuropathy
• Pharmacokinetics

ObjectiveThis study is aimed at facilitating clinician understanding of factors associated with postbariatric surgery neuropathic pain (PBSNP) and discussing the evidence base for management options.
DesignA case report and systematic literature review.
MethodsA search was conducted of PubMed, MEDLINE, Google Scholar, EMBASE, Psych Info, and Cochrane Database of Reviews for articles published between 1985 and 2013 on neuropathy, pain, and pharmacokinetics associated with postbariatric surgery.
ResultsThe epidemiology of PBSNP has not been well established, and current therapeutic options are not evidence based. Available data indicate up to 33% incidence of pain in patients with neuropathy after bariatric surgery, resulting in significant decreases in quality of life and increases in health care costs. Pathophysiologic mechanisms underlying PBSNP are unclear, and the natural course is variable, with some patients experiencing spontaneous improvement when nutritional deficiency is identified and corrected. Early identification of nutritional deficiency along with glycemic and lipid control may prevent or partially reverse postsurgical neuropathy and modulate PBSNP.
ConclusionsA better understanding of the peripheral and central mechanisms resulting in PBSNP is likely to promote the development of targeted and effective treatments.

• 出版日期2015-2