Acute Pancreatitis Following Peptide Receptor Radionuclide Therapy: An Unusual Adverse Event

作者:Karfis Ioannis*; Marin Gwennaelle; Machiels Godelieve; Hendlisz Alain; Flamen Patrick
来源:Clinical Nuclear Medicine, 2018, 43(7): E232-E233.
DOI:10.1097/RLU.0000000000002118

摘要

A 54-year-old man with grade 2 rectal neuroendocrine tumor and hepatic, pancreatic, and bone metastases was treated with Lu-177-DOTATATE as second-line therapy, after failure of somatostatin analogues. Two weeks after the first injection, he presented at the emergency department with acute pancreatitis. We hypothesized that this unusual adverse event, never been reported so far, was the result of acute tumor irradiation after PRRT, leading to peritumoral inflammation and edema with obstruction of an accessory pancreatic duct.

  • 出版日期2018-7