A tight 1:1 complex between an allosteric receptor and an organic effector with hydrogen and coordination bonds

作者：Sasaki Yoshito; Suzuki Shuichi; Okada Keiji; Kozaki Masatoshi^*

来源：Tetrahedron Letters, 2016, 57(36): 4082-4085.

DOI：10.1016/j.tetlet.2016.07.088

• Allosteric receptor
• Porphyrin
• Hydrogen bonds
• Supramolecule
• Binding constants

An allosteric system I was constructed by introducing a linear conjugated chain at position 1 and two side chains at positions 2 and 6 on the benzene ring. The conjugated chain consists of a zinc diethynyldiphenylporphyrin center (ZnDEDPP) extended to a diamidopyridine terminal. The side arm has a zinc tetraphenylporphyrin terminal (ZnTPP) linked by flexible ethylenedioxy groups. The organic effector 2, possessing a uracil and two pyridine units, formed a tight 1:1 supramolecular complex with 1. The binding constant of ZnDEDPP in 1 with 4-phenylpyridine was 4.2 times larger than that of ZnDEDPP in 1.2, indicating that compound 2 functions as an allosteric effector for the complexation of 1 and 4-phenylpyridine.

• 出版日期2016-9-7