The impact of eNOS, MTR and MTHFR polymorphisms on renal graft survival in children and young adults

作者：Artifoni Lina^*; Benetti Elisa; Centi Sonia; Negrisolo Susanna; Ghiggeri Gian Marco; Ginevri Fabrizio; Ghio Luciana; Edefonti Alberto; Brambilla Caterina; Cagni Nicoletta; Murer Luisa

来源：Nephrology Dialysis Transplantation, 2009, 24(9): 2931-2937.

DOI：10.1093/ndt/gfp161

• allograft nephropathy
• graft survival
• polymorphisms
• renal transplantation

Methods. We carried out a genetic analysis of endothelial nitric oxide synthase (eNOS) 894G > T, methionine synthase (MTR) 2756A > G and methylenetetrahydrofolate reductase (MTHFR) 677C > T/1298A > C in 268 renal allograft recipient/donor (D/R) matches, with respect to long-term graft survival.
Results. While MTHFR 677C > T/1298A > G and MTR 2756A > G polymorphism distribution in both recipients (R) and donors (D) showed no significant difference between matches with loss of graft function and those with long-term graft survival, the frequency of the eNOS 894TT genotype of donors was significantly increased (P = 0.040) in matches with better graft survival. The multivariate analysis identified the eNOS 894 genotype and clinically acute rejection episodes as independent risk factors for graft loss (P = 0.0406 and P = 0.0093, respectively).
Conclusions. The association between eNOS 894G > T polymorphism of donors and graft survival seems to suggest a role for this gene in chronic allograft injury; however, further studies are needed to confirm this hypothesis.

• 出版日期2009-9